Pts with T315I were assigned to varying dose levels in phase 1, and 200 mg twice daily (BID) was selected for cohort expansion. Pts with uncontrolled cardiovascular conditions were excluded. Methods: This phase 1 study enrolled adults with CML in chronic phase (CP) or accelerated phase (AP) R/I ≥ 2 TKIs pts with T315I were eligible after receiving ≥ 1 TKI if no other effective therapy was available. Asciminib demonstrated clinical activity in heavily pretreated CML pts with or without mutations, with promising efficacy in pts with T315I, including those resistant to/intolerant of (R/I) PON. Asciminib has a distinct mechanism of action and is the first-in-class STAMP (Specifically Targeting the ABL Myristoyl Pocket) inhibitor. PON use, however, is limited in many patients by its safety profile. The T315I mutation confers resistance to all approved ATP-competitive TKIs except ponatinib (PON) and is associated with significantly worse clinical outcomes. However, resistance to treatment driven by point mutations in the ABL kinase domain, particularly the T315I mutation, represents a clinical challenge. ฿200,000 THB ( ~$6,383.Introduction: Tyrosine kinase inhibitors (TKIs) are an effective therapy for pts with CML. Bottom 5 of Regular Season relegated to PTC 2020 Phase 2.Following the APAC Finals cancellation announcement.Top 6 teams qualified to 2020 SEA Super Cup.Winner qualified directly to Global Series Berlin.Any roster changes cannot be made throughout the season.Each team will be allowed up to 7 players for the roster.
The 2020 competitive season will culminated at the PUBG Global Championship 2020. The series represents Thailand's portion of the 2020 SEA Super Cup held by PUBG Corporation. PUBG Thailand Series is a PUBG professional series in Thailand.
0 kommentar(er)
